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Merck
CN

SML3207

MB05032

≥98% (HPLC)

Synonym(s):

2-Amino-5-isobutyl-4-[5-phosphono-2-furanyl]thiazole, 5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid, CS-917 active drug, MB 05032, MB-05032, MB-06322 active drug, MB06322 active drug, [5-[2-Amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid

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About This Item

Empirical Formula (Hill Notation):
C11H15N2O4PS
CAS Number:
261365-11-1
Molecular Weight:
302.29
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD14584901
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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SMILES string

[P](=O)(O)(O)c1[o]c(cc1)c2nc([s]c2CC(C)C)N

InChI

1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16)

InChI key

XJMYIJPPDSZOPN-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

AMP site-targeting, potent and selective fructose-1,6-bisphosphatase (FBPase) inhibitor that suppresses cellular gluconeogenesis (GNG).
MB05032 is an AMP site-targeting, potent and selective fructose-1,6-bisphosphatase (FBPase) inhibitor (rec hum liver FBPase IC50 = 16 nM, purified hum muscle/rat liver FBPase IC50 = 29/61 nM) with no potency toward glycogen phosphorylase or AMP-activated protein kinase. MB05032 inhibits cellular (rat/human hepotocytes IC50/glucose gluconeogenesis (GNG) substrate = 7.8 ?M/lactate & pyruvate/rat hepotocytes, 47.5 μM/lactate/human hepotocytes).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000141348
0000141349
0000138166

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