SML3227
KI-ARv-03
≥98% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C14H21N5
CAS Number:
Molecular Weight:
259.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
(Powder or Lyophilized powder or film or oil)
Quality Segment
assay
≥98% (HPLC)
form
(Powder or Lyophilized powder or film or oil)
color
colorless to brown-yellow
storage temp.
2-8°C
SMILES string
CCCC1=NC2=CC=NN2C(N[C@H]3C[C@@H](CC3)N)=C1
Biochem/physiol Actions
KI-ARv-03 is a cell penetrant, potent and selective inhibitor of CDK9 that that reduces AR-driven transcription and proliferation in prostate cancer cells. KI-ARv-03 modulates AR and AR-V7-dependent transcription in 22Rv1 cells. It exhibits potent anti-tumor activity in castration-resistant prostate cancer (CRPC) models.
Orally available, potent, ultraselective CDK9 inhibitor that exhibits potent anti-tumor activity in castration-resistant prostate cancer (CRPC) models
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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