SML3240
CL264
≥98% (HPLC)
Synonym(s):
2-(4-((6-Amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzamido)acetic acid, CL 264, CL-264, N-[4-[[6-Amino-2-(butylamino)-7,8-dihydro-8-oxo-9H-purin-9-yl]methyl]benzoyl]glycine
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About This Item
Empirical Formula (Hill Notation):
C19H23N7O4
CAS Number:
Molecular Weight:
413.43
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
General description
CL264 is a hydrophilic molecule. CL264,an adenine analog, is a potent and selective toll-like receptor 7 (TLR7) agonist with no TLR8-stimulating potency. This bioactive small molecule belongs to the category of 9-benzyl-8-hydroxyadenine derivatives. It contains a glycine molecule attached to the benzyl group. Studies show that CL264 is capable of activating NF-κB and stimulating the secretion of IFN-α in cells that express TLR7. CL264 is commonly used at a concentration range from 2 ng/mL to 10 μg/mL for stimulating cells in cultures.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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TLR7 agonist loaded airway epithelial targeting nanoparticles stimulate innate immunity and suppress viral replication in human bronchial epithelial cells
Kan
International Journal of Pharmaceutics, 5, 5:617:121586-5:617:121586 (2022)
Tobias Hilbert et al.
Mediators of inflammation, 2015, 948540-948540 (2016-01-16)
TLR7 ligation in plasmacytoid dendritic cells is promising for the treatment of cancer, allergy, and infectious diseases; however, high doses of ligands are required. We hypothesized that the combination of structurally different TLR7 ligands exponentiates the resulting immune response. CAL-1
Joseph Skurski et al.
Frontiers in cellular and infection microbiology, 10, 620392-620392 (2021-02-16)
A well-controlled innate immune response is characterized by a rapid yet self-limiting inflammatory response. Although much is known about the range of inflammatory stimuli capable of triggering an innate immune response, the mechanisms which govern the degree of inflammation induced
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3240-5MG | 04065267521183 |
| SML3240-25MG | 04065267521176 |