SML3244
CU-CPD107
≥98% (HPLC)
Synonym(s):
2-(Ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl-1H-imidazole-1-ethanol
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About This Item
Empirical Formula (Hill Notation):
C16H21IN2O2
CAS Number:
Molecular Weight:
400.25
UNSPSC Code:
51111800
NACRES:
NA.77
InChI
1S/C16H21IN2O2/c1-4-21-10-13-18-15(17)14(12-8-6-5-7-9-12)19(13)11-16(2,3)20/h5-9,20H,4,10-11H2,1-3H3
InChI key
XCYMSVIYUJTAPJ-UHFFFAOYSA-N
SMILES string
CC(C)(O)CN(C(COCC)=N1)C(C2=CC=CC=C2)=C1I
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
CU-CPD107 is a selective and potent inhibitor of Resiquimod-induced Toll-like receptor 8 (TLR8) signaling. Additionally, CU-CPD107 acts as TLR8 agonist in the presence of ssRNA. CU-CPD107 alone is unable to modulate TLR8 signaling.
Selective and potent inhibitor of Resiquimod-induced Toll-like receptor 8 (TLR8); TLR8 agonist in the presence of ssRNA
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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Yi Yang et al.
Nature communications, 12(1), 4351-4351 (2021-07-18)
Small-molecule modulators of TLR8 have drawn much interests as it plays pivotal roles in the innate immune response to single-stranded RNAs (ssRNAs) derived from viruses. However, their clinical uses are limited because they can invoke an uncontrolled, global inflammatory response.
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