SML3252
SF3B1 Protein Degrader
≥95% (HPLC)
Synonym(s):
2-((4-chlorophenyl)amino)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)thiazole-4-carboxamide, O4I2-based PROTAC® degrader
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C29H29ClN6O5S
Molecular Weight:
609.10
UNSPSC Code:
12352202
NACRES:
NA.77
Product Name
SF3B1 Protein Degrader, ≥95% (HPLC)
InChI key
UWYLVQJEOCYCEW-UHFFFAOYSA-N
SMILES string
O=C1N(C(C2=C1C=CC=C2NCCCCCCNC(C3=CSC(NC4=CC=C(C=C4)Cl)=N3)=O)=O)C5CCC(NC5=O)=O
assay
≥95% (HPLC)
form
powder
storage condition
under inert gas
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable degrader of splicing factor 3B1 (SF3B1)
SF3B1 Protein degrader (reported as "PROTAC-O4I2" in Gama-Brambila et al.) is a cell permeable degrader of splicing factor 3B1 (SF3B1) containing an SF3B1 activator O4I2 connected to the ligand of the cereblon ubiquitin ligase thalidomide. PROTAC-O4I2 selectively degrades SF3B1 in cells. It induces apoptosis of tumor cells and extends survival in Drosophila intestinal tumor model.
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Rodrigo A Gama-Brambila et al.
Cell chemical biology, 28(11), 1616-1627 (2021-05-29)
The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service