SML3254
Aloperine
≥98% (HPLC)
Synonym(s):
Alop1 compound,(7-alpha,9-alpha)-9-De-2-piperidinyl-16,17-didehydro-ormosanine, ALO, (6R,6aR,13R,13aS)-1,3,4,6,6a,7,8,9,10,12,13,13a-Dodecahydro-6,13-methano-2H-dipyrido[1,2-a:3′,2′-e]azocine, Ormosanine
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About This Item
Empirical Formula (Hill Notation):
C15H24N2
CAS Number:
Molecular Weight:
232.36
UNSPSC Code:
12352107
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D 73 to 89°, c = 0.5 g/mL in ethanol
color
white to beige
mp
67-72 °C
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[H][C@]12CN3CCCC[C@]3([H])[C@]([H])(C1)C=C4CCCN[C@@]24[H]
InChI
1S/C15H24N2/c1-2-7-17-10-13-9-12(14(17)5-1)8-11-4-3-6-16-15(11)13/h8,12-16H,1-7,9-10H2/t12-,13+,14+,15+/m0/s1
InChI key
SKOLRLSBMUGVOY-GBJTYRQASA-N
General description
Aloperine is a quinolizidine-type alkaloid found in the seeds and leaves of the herbal plant, Sophora alopecuroides L. It possesses antiviral, anticancer, antioxidant, and anti-inflammatory activity. Aloperine exhibits antifibrotic activity in mouse models of pulmonary fibrosis, and anticancer activity in human osteosarcoma and thyroid cancer cells. It also exhibits neuroprotective effects against oxidative stress in early brain injury, and antiviral activity as a human immunodeficiency virus-1 (HIV-1) entry inhibitor. Aloperine also has the ability to inhibit migration and invasion of liver cancer cells, as well as disrupt the cell cycle, and mitigate cell growth at various phases. It can hinder the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway.
Application
Aloperine may be used to study its effects on allergic airway inflammation in the murine asthma model and to compare its anti-asthmatic activity.
Biochem/physiol Actions
Alkaloid with antiviral, anticancer, antioxidant, and anti-inflammatory activity
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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