SML3261
JS6
≥98% (HPLC)
Synonym(s):
2-(2-Fluorobenzamido)-N-[2-(morpholin-4-yl)ethyl]benzamide, 2-Fluoro-N-(2-(2-morpholinoethylcarbamoyl)phenyl)benzamide, 2-[(2-Fluorobenzoyl)amino]-N-[2-(4-morpholinyl)ethyl]benzamide
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About This Item
Empirical Formula (Hill Notation):
C20H22FN3O3
CAS Number:
Molecular Weight:
371.41
UNSPSC Code:
12352107
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC=CC=C1NC(C2=C(C=CC=C2)F)=O)NCCN3CCOCC3
InChI key
QEEPXSHOUBCRGQ-UHFFFAOYSA-N
Biochem/physiol Actions
Bcl3:NF-kB p50 protein-protein interaction (PPI) inhibitor with anti-metastatic efficacy in cultures and in vivo.
JS6 is a Bcl3:NF-kB p50 protein-protein interaction (PPI) inhibitor that effectively suppresses Bcl3-dependent intracellular NF-kB activity (IC50 = 45/159 nM using Bcl3-overexpressing MDA-MB-231/HEK293; IC50 = 710 nM using HEK293 overexpressing Bcl3 and NF-kB p52). JS6 prevents enhanced MDA-MB-231 migration upon Bcl3 overexpression in cultures (IC50 = 310 nM), and effectively suppresses primary tumor growth as well as secondary tumor colonisation in vivo (3.5-10 mg/kg/d i.p. mice with MDA-MB-436 or 4T1.2 murine carcinoma xenograft) without overt systemic toxicity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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