SML3265
DAPTA trifluoroacetate
≥95% (HPLC)
Synonym(s):
Adaptavir trifluoroacetate, D-Ala-Peptide T-NH2 trifluoroacetate, D-Ala-Peptide T-amide trifluoroacetate, Dala1-Peptide T-NH2 trifluoroacetate, Dala1-Peptide T-amide trifluoroacetate, H-D-Ala-STTTNYT-NH2 trifluoroacetate, H-D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2 trifluoroacetate, [D-Ala1]-Peptide T-NH2 trifluoroacetate, [D-Ala1]-Peptide T-amide trifluoroacetate
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About This Item
NACRES:
NA.77
UNSPSC Code:
51111800
Biochem/physiol Actions
DAPTA is a potent CCR5 antagonist, an amidated octapeptide corresponding to an HIV envelope glycoprotein gp120 (gp160)-derived sequence (aa 185-192; the SF-2 isolate) that competes against gp120-CD4 complex for interaction with CCR5 (IC50 = 0.42 nM against gp120CM235 binding to CCR5/CD4 cells, IC50 = 1.5/1.8 nM against gp120BaL/sCD4 or gp120CM235/sCD4 binding to CCR5+/CD4- cells). DAPTA blocks CCR5-dependent HIV host cell entry in cultures and in vivo.
Potent CCR5 antagonist that blocks CCR5-dependent HIV host cell entry in cultures and in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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AIDS (London, England), 34(7), 979-988 (2020-02-20)
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Sheikh F Ahmad et al.
European journal of pharmacology, 846, 100-108 (2019-01-19)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3265-1MG | 04065268005125 |