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SML3271

Etoricoxib

Name: Etoricoxib
Brand: SIGMA

≥95% (HPLC), COX-2 inhibitor, powder

Synonym(s):

5-Chloro-3-[4-(methylsulfonyl)phenyl]-2-(2-methyl-5-pyridinyl)pyridine, 5-Chloro-6′-methyl-3-[4-(methylsulfonyl)phenyl]-2,3′-bipyridine

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₅ClN₂O₂S

CAS Number:

202409-33-4

Molecular Weight:

358.84

UNSPSC Code:

12352107

NACRES:

NA.77

MDL number:

MFCD06797512

Beilstein/REAXYS Number:

8073797

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

Etoricoxib, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=NC=C(C2=C(C3=CC=C(S(C)(=O)=O)C=C3)C=C(Cl)C=N2)C=C1

InChI

1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3

InChI key

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Description

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pictograms

GHS06

signalword

Danger

hcodes

H302,H310

pcodes

P262 - P264 - P270 - P280 - P301 + P312 - P302 + P352 + P310

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 4 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

Regulatory Information

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Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

D Riendeau et al.

The Journal of pharmacology and experimental therapeutics, 296(2), 558-566 (2001-02-13)

We report here the preclinical profile of etoricoxib (MK-0663) [5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) pyridine], a novel orally active agent that selectively inhibits cyclooxygenase-2 (COX-2), that has been developed for high selectivity in vitro using whole blood assays and sensitive COX-1 enzyme assays at

The Role of Organic Small Molecules in Pain Management.

Sebastián A Cuesta et al.

Molecules (Basel, Switzerland), 26(13) (2021-07-20)

In this review, a timeline starting at the willow bark and ending in the latest discoveries of analgesic and anti-inflammatory drugs will be discussed. Furthermore, the chemical features of the different small organic molecules that have been used in pain

Anti-proliferative and apoptotic effects of etoricoxib, a selective COX-2 inhibitor, on 1,2-dimethylhydrazine dihydrochloride-induced colon carcinogenesis.

Lalita Tanwar et al.

Asian Pacific journal of cancer prevention : APJCP, 11(5), 1329-1333 (2011-01-05)

In the present study, we assessed effects of etoricoxib, a non-steroidal anti-inflammatory drug, on proliferation and apoptosis in 1,2-dimethylhydrazine dihydrochloride (DMH) induced colon lesion development. Male SD rats were divided into four groups: Group 1 controls receiving the vehicle treatment;

Global Trade Item Number

SKU	GTIN
SML3271-50MG	04065267033204
SML3271-10MG	04065267033198