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Merck
CN

SML3273

XAF-1407

≥98% (HPLC)

Synonym(s):

(3-methyl-1-[5-phenyl-4-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidin-6-yl]azetidin-3-ol)

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About This Item

Empirical Formula (Hill Notation):
C28H37N5O2S
Molecular Weight:
507.69
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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InChI key

AVTFTJSBFXQTLR-UHFFFAOYSA-N

InChI

1S/C28H37N5O2S/c1-28(34)18-33(19-28)27-23(22-7-3-2-4-8-22)24-25(29-20-30-26(24)36-27)32-13-9-21(10-14-32)17-35-16-15-31-11-5-6-12-31/h2-4,7-8,20-21,34H,5-6,9-19H2,1H3

SMILES string

OC1(CN(C1)C2=C(C3=C(N=CN=C3S2)N4CCC(CC4)COCCN5CCCC5)C6=CC=CC=C6)C

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Potent and highly selective inhibitor of the acetylcholine-activated inward rectifier potassium current (IKACh) that exhibits an antiarrhythmic effect
XAF-1407 is a potent and highly selective inhibitor of the acetylcholine-activated inward rectifier potassium current (IKACh) that exhibits an antiarrhythmic effect in a goat and horse models of atrial fibrillation. XAF-1407 potently and selectively inhibits ion channels formed by Kir3.1/3.4 heterotetramers and Kir3.4 homotetramers that carry the IKACh current (IC50 of 1.1 and 3.2 nM respectively).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000179544
0000179543
0000159861
0000159861
0000179544

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Merle Friederike Fenner et al.
British journal of pharmacology, 177(16), 3778-3794 (2020-05-22)
Inhibition of the G-protein gated ACh-activated inward rectifier potassium current, IK,ACh may be an effective atrial selective treatment strategy for atrial fibrillation (AF). Therefore, the anti-arrhythmic and electrophysiological properties of a novel putatively potent and highly specific IK,ACh inhibitor, XAF-1407
Vladimír Sobota et al.
Frontiers in pharmacology, 11, 608410-608410 (2021-02-16)
Aims: The acetylcholine-activated inward rectifier potassium current (IKACh) has been proposed as an atrial-selective target for the treatment of atrial fibrillation (AF). Using a novel selective IKACh inhibitor XAF-1407, the study investigates the effect of IKACh inhibition in goats with

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