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SML3289

Synucleozid dihydrochloride

≥98% (HPLC)

Synonym(s):

2-(4-(4-Carbamimidoylphenylamino)phenyl)-1H-indole-6-carboximidamide, dihydrochloride, 2-[4-(4-Carbamimidoylanilino)phenyl]-1H-indole-6-carboximidamide, dihydrochloride, 2-[4-[[4-(Aminoiminomethyl)phenyl]amino]phenyl]-1H-indole-6-carboximidamide, dihydrochloride, NSC 377363 2HCl, NSC-377363 2HCl, NSC377363 2HCl

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About This Item

Empirical Formula (Hill Notation):
C22H20N6 · 2HCl
Molecular Weight:
441.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD34470022
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

, White to very dark grey

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[nH]1c2c(cc1c3ccc(cc3)Nc4ccc(cc4)C(=N)N)ccc(c2)C(=N)N

InChI

1S/C22H20N6/c23-21(24)14-5-9-18(10-6-14)27-17-7-3-13(4-8-17)19-11-15-1-2-16(22(25)26)12-20(15)28-19/h1-12,27-28H,(H3,23,24)(H3,25,26)

InChI key

TZRXNWCLKYWDNH-UHFFFAOYSA-N

Biochem/physiol Actions

Selective α-synuclein (α-syn) translation inhibitor with cytoprotective efficacy against preformed α-syn fibrils (PFFs) in SH-SY5Y neuronal cultures.
Synucleozid is a selective α-synuclein (α-syn) translation inhibitor (46% & 69% α-syn downregulation post 48 h, respectively, with 0.5 or 1 μM Synucleozid) with cytoprotective efficacy against preformed α-synuclein fibrils (PFFs) in SH-SY5Y neuronal cultures (56% protection; 0.5 μM Synucleozid added 24 h prior to 48 h 50 μg/mL PFFs exposure). Synucleozid directly and selectively targets α-syn (SNCA) mRNA 5′ UTR at the iron-responsive element (IRE) site, effectively interfering with the polysomes assembly onto SNCA mRNA.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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