SML3300
TB21007
≥98% (HPLC)
Synonym(s):
3-(2-Hydroxyethylthio)-6,6-dimethyl-1-(thiazol-2-yl)-6,7-dihydrobenzo[c]thiophen-4(5H)-one, 6,6-Dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one, 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)benzo[c]thiophen-4(5H)-one, TB 21007, TB-21007
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About This Item
Empirical Formula (Hill Notation):
C15H17NO2S3
CAS Number:
Molecular Weight:
339.50
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1C2=C(SCCO)SC(C3=NC=CS3)=C2CC(C1)(C)C
InChI
1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3
InChI key
QILRYFCEXLFIDS-UHFFFAOYSA-N
Biochem/physiol Actions
Gamma-aminobutyric acid type A receptor GABA(A) alpha 5 (α5) subtype-selective inverse agonist/negative allosteric modulator (NAM) in vitro and in vivo.
TB21007 is a gamma-aminobutyric acid type A receptor (GABAA) alpha 5 (α5) subtype-selective (αβ3γ2 Ki in nM = 1.6/α5, 20/α1, 16/α2, 20/α3) negative allosteric modulator (NAM)/inverse agonist (% inhibition at 100 nM = 51/α5, 21/α1, 1/α2, 3/α3, using L(tk-) fibroblast expressing β3γ2 with respective α subunit). TB21007 enhances cognitive performance in a hippocampal-dependent memory task in vivo (0.3 mg/kg i.p. in rats; delayed ‘matching-to-place′ Morris water maze test) without the convulsant or proconvulsant activity (3 mg/kg i.p. in mice) observed with nonselective inverse agonists.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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