SML3306
BAY-390
≥98% (HPLC)
Synonym(s):
(1R,2R)-2-(4-Fluorophenylamino)-1-(trifluoromethyl)cyclohexanol, BAY 390, BAY390
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About This Item
Empirical Formula (Hill Notation):
C13H15F4NO
CAS Number:
Molecular Weight:
277.26
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
IESAJAZKMLPVIB-VXGBXAGGSA-N
SMILES string
FC1=CC=C(C=C1)N[C@H]2[C@@](C(F)(F)F)(CCCC2)O
assay
≥98% (HPLC)
form
oil
color
yellow to orange
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
BAY-390 is an orally active, potent and selective TRPA1 inhibitor (cellular Ca++ influx IC50 in nM by FLIPR = 16/hu, 19/monkey, 63/rat, 68/guinea pig, 73/mu, 81/dog; IC50 = 5.6 µM/hTRPC5, >25 µM/human TRPV1/4, TRPC3/6, KCNK9 (TASK-3), CACNA1H (Cav3.2)) that shows in vivo efficacy in animal models of inflammatory pain (30 or 90 mg/kg mice, p.o.) and neurogenic pain (30 or 90 mg/kg rats, b.i.d. p.o.).
Oally active, potent and selective TRPA1 inhibitor with in vivo efficacy in inflammatory and neurogenic pain models.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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