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SML3308

RyR1-selective inhibitor 1

≥98% (HPLC)

Synonym(s):

5,8-Dihydro-5-octyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C19H22NO5·Na
Molecular Weight:
367.37
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (Warmed)

storage temp.

room temp

Biochem/physiol Actions

Potent and selective inhibitor of the type 1 ryanodine receptor (RyR1)
RyR1-selective inhibitor 1 (6,7-(methylenedioxy)-1-octyl-4-quinolone-3-carboxylic acid) potently and selectively inhibits the type 1 ryanodine receptor (RyR1). It prevents and treats malignant hyperthermia and heat stroke in several mouse models. RyR1-selective inhibitor 1 decreases resting intracellular Ca2+, inhibits halothane- and isoflurane-induced Ca2+ release, and suppresses caffeine-induced contracture in skeletal muscle.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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