SML3308
RyR1-selective inhibitor 1
≥98% (HPLC)
别名:
5,8-Dihydro-5-octyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid sodium salt
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关于此项目
经验公式（希尔记法）:
C19H22NO5·Na
分子量:
367.37
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear (Warmed)
storage temp.
room temp
Biochem/physiol Actions
Potent and selective inhibitor of the type 1 ryanodine receptor (RyR1)
RyR1-selective inhibitor 1 (6,7-(methylenedioxy)-1-octyl-4-quinolone-3-carboxylic acid) potently and selectively inhibits the type 1 ryanodine receptor (RyR1). It prevents and treats malignant hyperthermia and heat stroke in several mouse models. RyR1-selective inhibitor 1 decreases resting intracellular Ca2+, inhibits halothane- and isoflurane-induced Ca2+ release, and suppresses caffeine-induced contracture in skeletal muscle.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable