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SML3309

DN01

≥98% (HPLC)

Synonym(s):

4-(4-((Dimethylamino)methyl)-2,6-dimethoxyphenyl)-7-fluoro-2-methylisoquinolin-1(2H)-one

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About This Item

Empirical Formula (Hill Notation):
C21H23FN2O3
CAS Number:
2965690-32-6
Molecular Weight:
370.42
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

, White to light brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

DN01 is a potent and selective BRD8 first bromodomain inhibitor (BRD8(1) IC50 = 12 nM; BRD4(1) & BRD9 IC50 ≥10 μM) that serves as a useful chemical probe for the selective engagement of BRD8 and enrichment of native NuA4 complexes.
Potent and selective BRD8 first bromodomain inhibitor for probing the engagement of BRD8 and enrichment of native NuA4 complexes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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