SML3310
DN02
≥98% (HPLC)
Synonym(s):
4-(4-((3-Aminoazetidin-1-yl)methyl)-2,6-dimethoxyphenyl)-7-fluoro-2-methylisoquinolin-1(2H)-one
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About This Item
Empirical Formula (Hill Notation):
C22H24FN3O3
Molecular Weight:
397.44
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
DN02 is a potent and selective BRD8 first bromodomain inhibitor (BRD8(1) IC50 = 48 nM, BRD4(1) & BRD9 IC50 ≥10 μM; Kd = 34 nM/BRD8(1), >1 μM/BRD8(2), CBP, p300) that serves as a useful chemical probe for the selective engagement of BRD8 and enrichment of native NuA4 complexes.
Potent and selective BRD8 first bromodomain inhibitor for probing the engagement of BRD8 and enrichment of native NuA4 complexes.
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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