SML3312
SRI-41315
≥95% (HPLC), readthrough agent, powder
Synonym(s):
2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
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About This Item
Empirical Formula (Hill Notation):
C22H19N3O2
CAS Number:
Molecular Weight:
357.41
UNSPSC Code:
51111800
NACRES:
NA.32
Product Name
SRI-41315, ≥95% (HPLC)
SMILES string
O=C1N(C2=CC=CC=C2)C(C3CCC3)=NC4=C1C(C5=CC=CC=C5N4C)=O
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon
SRI-41315 is a cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon and allows translation elongation to continue in the correct reading frame and generate a full-length protein. SRI-41315 induces the translational pause that occurs at premature termination codons by depleting eRF1 protein levels through a proteasome-mediated degradation pathway. SRI-41315 restores CFTR expression and function in in immortalized and primary human bronchial epithelial cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jyoti Sharma et al.
Nature communications, 12(1), 4358-4358 (2021-07-18)
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination at PTCs. Poor efficacy of current readthrough agents prompted us
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