SML3320
KRA-533
≥98% (HPLC)
Synonym(s):
4-(4-(2-Bromoacetamido)butyl)benzoic acid, 4-[4-[(Bromoacetyl)amino]butyl]benzoic acid, KRAS Agonist-533, NSC 112533, NSC112533, p-[4-(2-Bromoacetamido)butyl]benzoic acid
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About This Item
Empirical Formula (Hill Notation):
C13H16BrNO3
CAS Number:
Molecular Weight:
314.18
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(O)C1=CC=C(CCCCNC(CBr)=O)C=C1
InChI
1S/C13H16BrNO3/c14-9-12(16)15-8-2-1-3-10-4-6-11(7-5-10)13(17)18/h4-7H,1-3,8-9H2,(H,15,16)(H,17,18)
InChI key
WZQJLTLURXNPQG-UHFFFAOYSA-N
Biochem/physiol Actions
KRA-333 is a potent and selective KRAS agonist that binds directly to the GTP/GDP binding pocket of KRAS preventing the cleavage of GTP into GDP and caucusing accumulation of activated GTP-KRAS and suppression of cell growth. KRA-333 promotes apoptosis and autophagic cell death of cancer cells and inhibits growth of mutant KRAS lung cancer in xenografts mice model.
Potent and selective KRAS agonist that binds directly to the GTP/GDP binding pocket caucusing accumulation of activated GTP-KRAS and suppression of cell growth
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
Xu K, Park D, Magis AT, Zhang J, Zhou W, Sica GL, Ramalingam SS, Curran WJ, Deng X
Molecular Cancer, 18 (2019)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3320-5MG | 04065268039717 |
| SML3320-25MG | 04065268039700 |