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SML3323

MS9715

≥98% (HPLC)

Synonym(s):

(2S,4R)-1-((S)-2-(9-(4-((4-(5-(7-fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylbenzyl)amino)butanamido)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C58H74FN9O5S
Molecular Weight:
1028.33
UNSPSC Code:
12352200
NACRES:
NA.32
Assay:
≥98% (HPLC)
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=C(C(C)=CC(CNCCCC(NCCCCCCCCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C=C3)C4=C(N=CS4)C)C)=O)=O)C(C)(C)C)=O)=O)=C1)C5=C(N(C=N5)C)C6=CC=NC7=C6C=CC(F)=C7

InChI

1S/C58H74FN9O5S/c1-36-28-40(29-37(2)51(36)52-53(67(8)34-63-52)46-24-27-61-47-30-43(59)22-23-45(46)47)32-60-25-15-17-49(70)62-26-14-12-10-9-11-13-16-50(71)66-55(58(5,6)7)57(73)68-33-44(69)31-48(68)56(72)65-38(3)41-18-20-42(21-19-41)54-39(4)64-35-74-54/h18-

InChI key

RWXCSOWWDBANDF-LPFSXYLXSA-N

Biochem/physiol Actions

MS9715 is a potent and highly selective degrader (PROTAC) of NSD3 (Nuclear receptor binding SET domain protein 3) that effectively depletes NSD3 and the associated cMyc oncogenic node. MS9715 comprised of NSD3 antagonist BI-9321 linked to an E3 ligase VHL ligand. It potently inhibits growth of NSD3-dependent hematological cancer cells.
Potent and highly selective degrader (PROTAC) of NSD3 that effectively depletes NSD3 and the associated cMyc oncogenic node

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000200788
0000200787
0000191869
0000191869
0000200788

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Global Trade Item Number

SKUGTIN
SML3323-25MG04065268039755
SML3323-5MG04065268039762