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SML3324

UNC6852

≥98% (HPLC)

Synonym(s):

(2S,4R)-1-((S)-2-(4-(4-(5-((furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C43H48N10O6S
CAS Number:
2688842-08-0
Molecular Weight:
832.97
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

SMILES string

O=C([C@H](C(C)(C)C)NC(CCCNC(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)=O)=O)N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5

InChI key

PPNNFXIBKLCMTI-WXEAQWFJSA-N

Biochem/physiol Actions

UNC6852 is a potent degrader of polycomb repressive complex 2 (PRC2) that targets EED. UNC6852 selectively degrades PRC2 components EED (embryonic ectoderm development), EZH2 (enhancer of zeste homolog 2), and SUZ12 (suppressor of zeste homolog 12) via recruitment of VHL. UNC6852 exhibit anticancer activities in model systems.
potent degrader of polycomb repressive complex 2 (PRC2) that targets EED

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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