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Merck
CN

SML3324

UNC6852

≥98% (HPLC)

Synonym(s):

(2S,4R)-1-((S)-2-(4-(4-(5-((furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C43H48N10O6S
CAS Number:
2688842-08-0
Molecular Weight:
832.97
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

UNC6852, ≥98% (HPLC)

InChI key

PPNNFXIBKLCMTI-WXEAQWFJSA-N

SMILES string

O=C([C@H](C(C)(C)C)NC(CCCNC(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)=O)=O)N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

UNC6852 is a potent degrader of polycomb repressive complex 2 (PRC2) that targets EED. UNC6852 selectively degrades PRC2 components EED (embryonic ectoderm development), EZH2 (enhancer of zeste homolog 2), and SUZ12 (suppressor of zeste homolog 12) via recruitment of VHL. UNC6852 exhibit anticancer activities in model systems.
potent degrader of polycomb repressive complex 2 (PRC2) that targets EED

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Revathi Raman et al.
Scientific reports, 11(1), 15238-15238 (2021-07-29)
Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits factor VIIa and Xa in the coagulation cascade. It has been shown that forkhead box P3 protein is a TFPI transcriptional repressor. However, there are no studies on chromatin
Frances Potjewyd et al.
Cell chemical biology, 27(1), 47-56 (2019-12-14)
Protein degradation via the use of bivalent chemical degraders provides an alternative strategy to block protein function and assess the biological roles of putative drug targets. This approach capitalizes on the advantages of small-molecule inhibitors while moving beyond the restrictions

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