SML3336
VU0155056
≥98% (HPLC)
Synonym(s):
5W0, ML272, N-(2-{4-[2-Oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}ethyl)-2-naphthamide, N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-2-naphthalenecarboxamide, VU 0155056
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About This Item
Empirical Formula (Hill Notation):
C25H26N4O2
CAS Number:
Molecular Weight:
414.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Catalytic site-targeting dual phospholipase D1 & D2 (PLD1 & PLD2) inhibitor.
VU0155056 is a catalytic site-targeting phospholipase D inhibitor (PLD1/PLD2 IC50 = 81 nM/240 nM by cell-free enzymatic assays; substrate = di-palmitoyl-PLC) that effectively suppresses the cellular PLD activity in GFP-PLD2-overexpressing HEK293 cells as well as PMA-stimulated non-small-cell lung cancer (NSCLC) Calu-1 cells with predominant PLD1 activity (IC50 = 380 nM and 21 nM, respectively).
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Regulatory Information
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Jeffrey L Barr et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Orexin A, an endogenous peptide involved in several functions including reward, acts via activation of orexin receptors OX1 and OX2, Gq-coupled GPCRs. We examined the effect of a selective OX1 agonist, OXA (17-33) on cytosolic calcium concentration, [Ca2+]i, in neurons
Amanda R Noble et al.
British journal of cancer, 121(12), 1016-1026 (2019-11-02)
Phospholipases D1 and D2 (PLD1/2) are implicated in tumorigenesis through their generation of the signalling lipid phosphatidic acid and its downstream effects. Inhibition of PLD1 blocks prostate cell growth and colony formation. Here a role for PLD2 in prostate cancer
Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver.
Mukesh Kumar et al.
The Journal of cell biology, 218(11), 3697-3713 (2019-10-13)
Triglyceride-rich lipid droplets (LDs) are catabolized with high efficiency in hepatocytes to supply fatty acids for producing lipoprotein particles. Fasting causes a massive influx of adipose-derived fatty acids into the liver. The liver in the fasted state is therefore bloated
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3336-25MG | 04065268975060 |
| SML3336-5MG | 04065268975077 |