Skip to Content

Key Documents

View All Documentation

SML3338

NF-56-EJ40

≥98% (HPLC)

Synonym(s):

2-(2-(4′-((4-Methylpiperazin-1-yl)methyl)biphenyl-3-ylcarboxamido)phenyl)acetic acid, 2-(2-(4′-((4-methylpiperazin-1-yl)methyl)-[1,1′-biphenyl]-3-carboxamido)phenyl)acetic acid, 2-[[[4′-[(4-Methyl-1-piperazinyl)methyl][1,1′-biphenyl]-3-yl]carbonyl]amino]-benzeneacetic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C27H29N3O3
CAS Number:
2380230-73-7
Molecular Weight:
443.54
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD32263439
Assay:
≥98% (HPLC)
Form:
powder
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Biochem/physiol Actions

High-affinity, human-selective SUCNR1 (GPR91) antagonist that blocks human GPR91-mediated cellular signaling with no activity towards rat species.
NF-56-EJ40 is a high-affinity, potent and human species-selective succinate receptor SUCNR1 (GPR91) antagonist (human GPR91 Ki/KD = 17.4/33 nM; GTPγS assay IC50 = 25 nM/human, >100 μM/rat). Extracellular succinate is reported to hyperpolarize M2 macrophages through GPR91-mediated Gq signaling, blockable by NF-56-EJ40 (1 μM) or Gq inhibitor YM-254890 (1 μM).

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library