SML3352
GSK973
≥98% (HPLC)
Synonym(s):
(2S,3S)-N5-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N7-methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide
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About This Item
Empirical Formula (Hill Notation):
C23H23FN2O4
CAS Number:
Molecular Weight:
410.44
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Orally available, potent and selective pan-second bromodomain (BD2) inhibitor that effectively inhibits LPS-induced MCP-1 release in human whole blood.
GSK973 is an orally available, potent and selective pan-second bromodomain (BD2) inhibitor (BD2/BD1 pIC50 = 7.5/4.4/BRD2, 7.8/4.5/BRD3, 7.8/4.6/BRD4, 7.4/4.5/BRDT) that effectively inhibits LPS-induced MCP-1 release in human whole blood (pIC50 = 7.3; IC50 = 50 nM).
GSK973 is an orally available, potent and selective pan-second bromodomain (BD2) inhibitor (BD2/BD1 pIC50 = 7.5/4.4/BRD2, 7.8/4.5/BRD3, 7.8/4.6/BRD4, 7.4/4.5/BRDT) that effectively inhibits LPS-induced MCP-1 release in human whole blood (pIC50 = 7.3; IC50 = 50 nM).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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