SML3353
GSK943
≥98% (HPLC)
Synonym(s):
(2R,3R)-N5-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N7-methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide
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About This Item
Empirical Formula (Hill Notation):
C23H23FN2O4
CAS Number:
Molecular Weight:
410.44
UNSPSC Code:
12352200
NACRES:
NA.21
InChI key
WZQLVEPIBAOOGF-PXTPFGJHSA-N
SMILES string
CNC(C1=C2C([C@](C3=CC=CC=C3)([H])[C@@H](O2)CF)=CC(C(N[C@@H]4[C@]5([H])[C@@]4([H])COC5)=O)=C1)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Inactive (2R,3R) stereoisomer of and the recommended negative control for the potent and selective pan-second bromodomain (BD2) inhibitor GSK973.
GSK943 corresponds to the inactive (2R,3R) stereoisomer of and the recommended negative control for the potent and selective pan-second bromodomain (BD2) inhibitor GSK973.
GSK943 corresponds to the inactive (2R,3R) stereoisomer of and the recommended negative control for the potent and selective pan-second bromodomain (BD2) inhibitor GSK973.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Alex Preston et al.
ACS medicinal chemistry letters, 11(8), 1581-1587 (2020-08-25)
Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclinical models and have entered the clinic in oncology trials where adverse events have been reported. These inhibitors interact equipotently with the eight bromodomains of the BET family
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