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Merck
CN

SML3353

Sigma-Aldrich

GSK943

≥98% (HPLC)

Synonym(s):

(2R,3R)-N5-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N7-methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide

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About This Item

Empirical Formula (Hill Notation):
C23H23FN2O4
CAS Number:
2139228-37-6
Molecular Weight:
410.44
UNSPSC Code:
12352200

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CNC(C1=C2C([C@](C3=CC=CC=C3)([H])[C@@H](O2)CF)=CC(C(N[C@@H]4[C@]5([H])[C@@]4([H])COC5)=O)=C1)=O

InChI key

WZQLVEPIBAOOGF-PXTPFGJHSA-N

Biochem/physiol Actions

Inactive (2R,3R) stereoisomer of and the recommended negative control for the potent and selective pan-second bromodomain (BD2) inhibitor GSK973.



GSK943 corresponds to the inactive (2R,3R) stereoisomer of and the recommended negative control for the potent and selective pan-second bromodomain (BD2) inhibitor GSK973.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000356327
0000356329
0000335087
0000356329
0000356327

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Alex Preston et al.
ACS medicinal chemistry letters, 11(8), 1581-1587 (2020-08-25)
Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclinical models and have entered the clinic in oncology trials where adverse events have been reported. These inhibitors interact equipotently with the eight bromodomains of the BET family

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