SML3359
TP-040
≥98% (HPLC)
Synonym(s):
N-((1-Methyl-1H-imidazol-4-yl)methyl)-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine
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About This Item
Empirical Formula (Hill Notation):
C15H22N6
CAS Number:
Molecular Weight:
286.38
UNSPSC Code:
51111800
NACRES:
NA.77
InChI
1S/C15H22N6/c1-12-4-7-21(8-5-12)14-3-6-16-15(19-14)17-9-13-10-20(2)11-18-13/h3,6,10-12H,4-5,7-9H2,1-2H3,(H,16,17,19)
InChI key
PWKAYICUBVNJAZ-UHFFFAOYSA-N
SMILES string
CC(CC1)CCN1C2=CC=NC(NCC3=CN(C)C=N3)=N2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Brain penetrant, potent and selective inhibitor of O-GlcNAcase (OGA).
TP-040 is a brain penetrant, potent and selective inhibitor of O-GlcNAcase (OGA). TP-040 increases the level of O-GlcNAcylated protein in cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Michiko Tawada et al.
Journal of medicinal chemistry, 64(2), 1103-1115 (2021-01-07)
O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokinetic profiles are desirable to characterize this enzyme. Herein, we report
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