SML3362
YM-244769 dihydrochloride
≥98% (HPLC)
Synonym(s):
N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride, N-(3-Aminobenzyl)-6-{4-[3-fluorobenzyl)oxy]phenoxy} nicotinamide dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C26H22FN3O3·2HCl
CAS Number:
Molecular Weight:
516.39
UNSPSC Code:
51111800
NACRES:
NA.21
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to pink
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4
InChI
1S/C26H22FN3O3/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18/h1-14,16H,15,17,28H2,(H,30,31)
InChI key
JZMLHJRKSJXARY-UHFFFAOYSA-N
Biochem/physiol Actions
Potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3
YM-244769 hydrochloride is a potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3. It inhibits the Ca2+ entry mode of NCX more potently than the Ca2+ exit mode. YM-244769 exhibits protection in various hypoxic/ischemic cell injury models with low cell toxicity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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