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Merck
CN

SML3362

YM-244769 dihydrochloride

≥98% (HPLC)

Synonym(s):

N-​[(3-​Aminophenyl)​methyl]​-​6-​[4-​[(3-​fluorophenyl)​methoxy]​phenoxy]​-3-​pyridinecarboxamide dihydrochloride, N-(3-Aminobenzyl)-6-{4-[3-fluorobenzyl)oxy]phenoxy} nicotinamide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C26H22FN3O3·2HCl
CAS Number:
1780390-65-9
Molecular Weight:
516.39
UNSPSC Code:
51111800
NACRES:
NA.21
MDL number:
MFCD28160863

Key Documents

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Product Name

YM-244769 dihydrochloride, ≥98% (HPLC)

InChI

1S/C26H22FN3O3/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18/h1-14,16H,15,17,28H2,(H,30,31)

InChI key

JZMLHJRKSJXARY-UHFFFAOYSA-N

SMILES string

O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to pink

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3
YM-244769 hydrochloride is a potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3. It inhibits the Ca2+ entry mode of NCX more potently than the Ca2+ exit mode. YM-244769 exhibits protection in various hypoxic/ischemic cell injury models with low cell toxicity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000220407
0000220406
0000220407
0000220406
0000208010

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Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death
Hu HJ, Wang SS, Wang YX, Liu Y, Feng XM, Shen Y, Zhu L, Chen HZ, Song M
British Journal of Pharmacology, 176, 2691-2707 (2019)
YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage
Iwamoto T, Kita S
Molecular Pharmacology, 70, 2075-2083 (2006)
Kanna Yamashita et al.
Naunyn-Schmiedeberg's archives of pharmacology, 389(11), 1205-1214 (2016-08-03)
Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and selective Na+/Ca2+ exchange (NCX) inhibitor by using various cells transfected with NCX using the 45Ca2+ fluorescent technique. However, the electrophysiological study of YM-244769 on NCX had not been

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