SML3366
SIS17
≥95% (HPLC)
Synonym(s):
N′-Hexadecylthiophene-2-carbohydrazide, SIS 17, SIS-17
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About This Item
Empirical Formula (Hill Notation):
C21H38N2OS
CAS Number:
Molecular Weight:
366.60
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[s]1c(ccc1)C(=O)NNCCCCCCCCCCCCCCCC
InChI
1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)
InChI key
HSHXDCVZWHOWCS-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Potent and selective HDAC11 inhibitor that effectively upregulates cellular serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level.
SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) that effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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