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SML3366

SIS17

≥95% (HPLC)

Synonym(s):

N′-Hexadecylthiophene-2-carbohydrazide, SIS 17, SIS-17

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About This Item

Empirical Formula (Hill Notation):
C21H38N2OS
CAS Number:
2374313-54-7
Molecular Weight:
366.60
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD32201127
Assay:
≥95% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

[s]1c(ccc1)C(=O)NNCCCCCCCCCCCCCCCC

InChI

1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)

InChI key

HSHXDCVZWHOWCS-UHFFFAOYSA-N

Biochem/physiol Actions

Potent and selective HDAC11 inhibitor that effectively upregulates cellular serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level.
SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) that effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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