SML3372
Glutipyran
≥98% (HPLC)
Synonym(s):
rel-N-(3,4-Dimethoxybenzyl)-N-((R)-3-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-3-phenylpropyl)furan-2-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C30H37NO5
Molecular Weight:
491.62
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
shipped in
dry ice
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Broad-spectrum potent and selective glucose transporter (GLUT) inhibitor
Glutipyran is a broad-spectrum potent and selective glucose transporter (GLUT) inhibitor that targets both GLUT1 and GLUT3. Glutipyran inhibits glycolytic activity and cell growth in PANC-1 cells (IC50 = 1.9 µM). It exhibits antitumor activity (12.5 mg/kg, i.v.) once daily in MIA PaCa-2 xenograft mouse model.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Makoto Kawatani et al.
ACS chemical biology, 16(8), 1576-1586 (2021-07-24)
Cancer cells reprogram their metabolism to survive and grow. Small-molecule inhibitors targeting cancer are useful for studying its metabolic pathways and functions and for developing anticancer drugs. Here, we discovered that glutipyran and its derivatives inhibit glycolytic activity and cell
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