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SML3375

WYE-687

≥98% (HPLC)

Synonym(s):

Methyl (4-{4-Morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)carbamate, Methyl N-[4-[4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate, WAY 687, WAY-687, WAY687, WYE 687, WYE687

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About This Item

Empirical Formula (Hill Notation):
C28H32N8O3
CAS Number:
1062161-90-3
Molecular Weight:
528.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD22417086
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N2(CCC(CC2)[n]3ncc4c3nc(nc4N6CCOCC6)c5ccc(cc5)NC(=O)OC)Cc1cnccc1

InChI

1S/C28H32N8O3/c1-38-28(37)31-22-6-4-21(5-7-22)25-32-26(35-13-15-39-16-14-35)24-18-30-36(27(24)33-25)23-8-11-34(12-9-23)19-20-3-2-10-29-17-20/h2-7,10,17-18,23H,8-9,11-16,19H2,1H3,(H,31,37)

InChI key

VDOCQQKGPJENHJ-UHFFFAOYSA-N

Biochem/physiol Actions

ATP-competitive, potent and selective mTOR inhibitor.
WYE-687 is an ATP-competitive, potent and selective mTOR inhibitor (IC50 = 7 nM; [ATP] = 100 μM) with much reduced or little potency toward other kinases (PI3Kα/PI3Kγ/CK1 γ1/p38α IC50 = 0.81/3.11/17.8/28.9 μM; IC50 >50 μM toward 22 other kinases). WYE-687 selectively inhibits IGF-I-stimulated phosphorylation of S6K1 pT389 over those of AKT pS473 & pS308 in Rat1 cells (0.3 nM), as well as suppresses mTOR-dependent proliferation in cancer cultures (PC3MM2/MDA-MB-361/LNCaP/A498 IC50 = 180/200/350/620 nM).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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