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Merck
CN

SML3376

Sigma-Aldrich

RTICBM-189

≥98% (HPLC)

Synonym(s):

N-(4-Chlorophenyl)-N′-[2-(3-chlorophenyl)ethyl]urea

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About This Item

Empirical Formula (Hill Notation):
C15H14Cl2N2O
CAS Number:
551909-15-0
Molecular Weight:
309.19
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NCCC1=CC(Cl)=CC=C1)NC2=CC=C(Cl)C=C2

InChI

1S/C15H14Cl2N2O/c16-12-4-6-14(7-5-12)19-15(20)18-9-8-11-2-1-3-13(17)10-11/h1-7,10H,8-9H2,(H2,18,19,20)

InChI key

PPKIPROVSKBYAT-UHFFFAOYSA-N

Biochem/physiol Actions

A blood brain barrier permeable, potent and selective negative allosteric modulator (NAM) of the cannabinoid CB1 receptor.
RTICBM-189 is a blood brain barrier permeable, potent and selective negative allosteric modulator (NAM) of the cannabinoid CB1 receptor. RTICBM-189 selectively attenuates reinstatement of the cocaine-seeking behavior in rats (10 mg/kg, i.p.).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000178076
0000174119
0000174119
0000178076

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Thuy Nguyen et al.
Journal of medicinal chemistry, 65(1), 257-270 (2021-12-21)
We have shown that CB1 receptor negative allosteric modulators (NAMs) attenuated the reinstatement of cocaine-seeking behaviors in rats. In an effort to further define the structure-activity relationships and assess the druglike properties of the 3-(4-chlorophenyl)-1-(phenethyl)urea-based CB1 NAMs that we recently

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