SML3376
RTICBM-189
≥98% (HPLC)
Synonym(s):
N-(4-Chlorophenyl)-N′-[2-(3-chlorophenyl)ethyl]urea
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About This Item
Empirical Formula (Hill Notation):
C15H14Cl2N2O
CAS Number:
Molecular Weight:
309.19
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(NCCC1=CC(Cl)=CC=C1)NC2=CC=C(Cl)C=C2
InChI
1S/C15H14Cl2N2O/c16-12-4-6-14(7-5-12)19-15(20)18-9-8-11-2-1-3-13(17)10-11/h1-7,10H,8-9H2,(H2,18,19,20)
InChI key
PPKIPROVSKBYAT-UHFFFAOYSA-N
Biochem/physiol Actions
A blood brain barrier permeable, potent and selective negative allosteric modulator (NAM) of the cannabinoid CB1 receptor.
RTICBM-189 is a blood brain barrier permeable, potent and selective negative allosteric modulator (NAM) of the cannabinoid CB1 receptor. RTICBM-189 selectively attenuates reinstatement of the cocaine-seeking behavior in rats (10 mg/kg, i.p.).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Thuy Nguyen et al.
Journal of medicinal chemistry, 65(1), 257-270 (2021-12-21)
We have shown that CB1 receptor negative allosteric modulators (NAMs) attenuated the reinstatement of cocaine-seeking behaviors in rats. In an effort to further define the structure-activity relationships and assess the druglike properties of the 3-(4-chlorophenyl)-1-(phenethyl)urea-based CB1 NAMs that we recently
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3376-5MG | 04065268504055 |
| SML3376-25MG | 04065268504048 |
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