SML3381
10-Hydroxy-trans-2-decenoic acid
≥98% (HPLC), osteoclastogenesis inhibitor, powder
Synonym(s):
(E)-10-Hydroxy-2-decenoic acid, 10-HAD, NSC 87516, Royal jelly acid, Trans-10-hydroxy-2-decenoic acid
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About This Item
Empirical Formula (Hill Notation):
C10H18O3
CAS Number:
Molecular Weight:
186.25
MDL number:
UNSPSC Code:
12352106
Product Name
10-Hydroxy-trans-2-decenoic acid, ≥98% (HPLC)
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
OCCCCCCC\C=C\C(=O)O
InChI
1S/C10H18O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h6,8,11H,1-5,7,9H2,(H,12,13)/b8-6+
InChI key
QHBZHVUGQROELI-SOFGYWHQSA-N
Biochem/physiol Actions
10-Hydroxy-2-decenoic acid is an orally available royal jelly component that potently inhibits osteoclastogenesis. It binds to free fatty acid receptor 4 (FFAR4) on osteoclasts which inhibits RANKL (receptor activator of nuclear factor-κB (NF-κB) ligand), thereby attenuating the induction of nuclear factor of activated T cells (NFAT) c1. 10-Hydroxy-2-decenoic acid inhibits bone resorption in ovariectomized mice.
Royal jelly component that potently inhibits osteoclastogenesis
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Mengmeng You et al.
European journal of pharmacology, 865, 172736-172736 (2019-10-16)
We previously reported that trans-10-hydroxy-2-decenoic acid (10-HDA), the exclusive lipid component of royal jelly (RJ), alleviates Lipopolysaccharide (LPS)-induced neuroinflammation both in vivo and in vitro. However, whether 10-HDA can protect against LPS-induced blood-brain barrier (BBB) damage is largely unexplored. In
Yosuke Tsuchiya et al.
The Journal of biological chemistry, 295(34), 12224-12232 (2020-07-11)
The supplementation of royal jelly (RJ) is known to provide a variety of health benefits, including anti-inflammatory and anti-obesity effects. RJ treatment also reportedly protects against bone loss, but no single factor in RJ has yet been identified as an
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