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Merck
CN

SML3403

HSip-1 DA trifluoroacetate hydrate

≥95% (HPLC)

Synonym(s):

Cyclen-AF-Cu DA trifluoroacetate hydrate, HSip 1 DA, HSip-1 diacetate trifluoroacetate hydrate, HSip1 DA, Hydrogen Sulfide imaging probe-1 DA, [N-(3′,6′-bis(Acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-5-yl)-1,4,7,10-tetraazacyclododecane-1-acetamide-κN1,κN4,κN7,κN10]-copper(2+) trifluoroacetate hydrate

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About This Item

Linear Formula:
C34H37CuN5O8· xCF3COOH· yH2O
UNSPSC Code:
41106609
NACRES:
NA.77

Key Documents

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SMILES string

O=C1OC2(C3=CC=C(NC(C[N]45CCN6CCN7CCN([Cu@+2]765)CC4)=O)C=C13)C8=CC=C(C=C8OC9=CC(OC(C)=O)=CC=C92)OC(C)=O.[y H2O]

assay

≥95% (HPLC)

form

powder

mol wt

707.23 g/mol

storage condition

protect from light

color

, Light Blue to Green Blue

solubility

H2O: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Cell-permeable HSip-1 diacetate precursor. Sensitive and selective intracellular hydrogen sulfide (H2S) fluorescent probe.
HSip-1 DA corresponds to the cell-permeable diacetate ester precursor of the sensitive hydrogen sulfide (H2S)-selective fluorescent turn-on probe HSip-1 (Cyclen-AF-Cu; Hydrogen Sulfide imaging probe-1). Once entering cells, HSip-1 DA is hydrolyzed by esterases to form HSip-1, allowing the selective detection of intracellular H2S by fluorescence (Ex 470-490 nm, Em 510-550 nm). For intracellular loading, incubate cells with 5-30 μM Hsip-1 DA in DMEM at 37 °C for 30 min before removing unincorporated probe by washing with HBSS.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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