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Merck
CN

SML3411

LY2828360

≥98% (HPLC)

Synonym(s):

8-(2-Chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine, LY 2828360

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About This Item

Empirical Formula (Hill Notation):
C22H27ClN6O
CAS Number:
1231220-79-3
Molecular Weight:
426.94
UNSPSC Code:
41121800
NACRES:
NA.77
MDL number:
MFCD28010855

Key Documents

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SMILES string

Clc1c(cccc1)c2[n](c4nc(nc(c4n2)N5CCN(CC5)C)C)C3CCOCC3

InChI

1S/C22H27ClN6O/c1-15-24-21(28-11-9-27(2)10-12-28)19-22(25-15)29(16-7-13-30-14-8-16)20(26-19)17-5-3-4-6-18(17)23/h3-6,16H,7-14H2,1-2H3

InChI key

UCMNDPDJRSEZPL-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist that inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.
Potent and selective slowly acting G protein-biased CB2 cannabinoid agonist

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000190889
0000190888
0000187071
0000190889
0000190888

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