SML3413
ASC-J9
≥98% (HPLC)
Synonym(s):
(1E, 4Z, 6E)-5-Hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one, Dimethylcurcumin, GO-Y025
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About This Item
Empirical Formula (Hill Notation):
C23H24O6
CAS Number:
Molecular Weight:
396.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
, White to light orange
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
OC(/C=C/C1=CC(OC)=C(C=C1)OC)=C\C(/C=C/C2=CC(OC)=C(C=C2)OC)=O
InChI
1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15-
InChI key
ZMGUKFHHNQMKJI-CIOHCNBKSA-N
Biochem/physiol Actions
ASC-J9 (dimethylcurcumin) is an androgen receptor (AR)-selective degradation promoter that disrupts the interaction between AR and its coregulators. ASC-J9 induces AR degration in cultures (5 µM, LNCaP) and shows in vivo therapeutic efficacy (50 mg/kg i.p. qod) in murine bladder cancer (TCC-SUP and UMUC3 xenografts) and a spinal and bulbar muscular atrophy disease model (AR-polyQ transgenic SBMA mice).
Androgen receptor (AR)-selective degradation promoter in cultures and in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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