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SML3415

Sigma-Aldrich

HBX 41,108

≥98% (HPLC)

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Synonym(s):
7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, HBX 41108, HBX-41108, HBX41108
Empirical Formula (Hill Notation):
C13H3ClN4O
CAS Number:
924296-39-9
Molecular Weight:
266.64
MDL number:
MFCD16251537

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=C2C=CC(Cl)=C1)C3=C2N=C(C(C#N)=N3)C#N

InChI

1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H

InChI key

BIGPXXAUSQLTQR-UHFFFAOYSA-N

Biochem/physiol Actions

HBX 41,108 is a catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease (USP) inhibitor (USP7/HAUSP IC50 = 420 nM) with little potency toward aspartic, serine or other non-USP cysteine proteases. HBX 41,108 exhibits antiproliferation potency in cancer cultures (HCT116 GI50 = 1 μM post 24 h treatment) by preventing USP7-mediated p53 deubiquitination and thereby promoting p53 target genes expression and inducing p53-dependent apoptosis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis.
Dong X, Xu X, Yang C, Luo Y, Wu Y, Wang J
Bone, 143, 115714-115714 (2021)
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells.
Molecular Cancer Therapeutics, 8, 2286-2295 (2009)
Hannah B L Jones et al.
Frontiers in chemistry, 9, 640105-640105 (2021-03-16)
The potency and selectivity of a small molecule inhibitor are key parameters to assess during the early stages of drug discovery. In particular, it is very informative for characterizing compounds in a relevant cellular context in order to reveal potential

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