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Merck
CN

SML3422

Pritelivir

≥98% (HPLC)

Synonym(s):

AIC316, BAY 57-1293, BAY57-1293, N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide

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About This Item

Empirical Formula (Hill Notation):
C18H18N4O3S2
CAS Number:
348086-71-5
Molecular Weight:
402.49
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD18633192
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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SMILES string

[S](=O)(=O)(N)c1[s]c(nc1C)N(C)C(=O)Cc2ccc(cc2)c3ncccc3

InChI

1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)

InChI key

IVZKZONQVYTCKC-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor with antiviral efficacy in cultures and in mice in vivo.
Pritelivir (AIC316; BAY57-1293) is a potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor (IC50 = 30 nM using wt HSV-1F ATPase complex UL5-UL52 & 1 mM ATP) with antiviral efficacy in Vero cultures (replication IC50 = 20 nM against HSV-2G, wt and Acyclovir-resistant HSV-1F; MOI = 0.0025) and in mice in vivo (ED50 = 0.5 mg/kg 3x daily p.o. using HSV-1 Walki or HSV-2 MS), being >28 times more potent than acyclovir and valacyclovir.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000186571
0000186571

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