SML3424
DIM-C-pPhOH
≥98% (HPLC)
Synonym(s):
1,1-Bis(3′-indolyl)-1-(p-hydroxyphenyl)methane, 4-(Di-1H-indol-3-ylmethyl)phenol; (4-Hydroxyphenyl)bis(1H-indol-3-yl)methane, 7,7-Bis(3-indolyl)-p-cresol, C-DIM 8, CDIM8
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About This Item
Empirical Formula (Hill Notation):
C23H18N2O
CAS Number:
Molecular Weight:
338.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
off-white to pink
solubility
DMSO: 2 mg/mL
storage temp.
−20°C
SMILES string
OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
InChI
1S/C23H18N2O/c26-16-11-9-15(10-12-16)23(19-13-24-21-7-3-1-5-17(19)21)20-14-25-22-8-4-2-6-18(20)22/h1-14,23-26H
InChI key
QCPDFNWJBQMXLI-UHFFFAOYSA-N
Biochem/physiol Actions
DIM-C-pPhOH is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhOH decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231breast cancer cells. DIM-C-pPhOH inhibits migration of Rh30 and MDA-MB-231 cancer cells.
NR4A1 (Nur77) antagonist that exhibit potent anticancer activity
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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