SML3430
Benvitimod
≥98% (HPLC), AHR immunomodulator, powder
Synonym(s):
(E)-2-Isopropyl-5-styrylbenzene-1,3-diol, 3,5-Dihydroxy-4-isopropyl-trans-stilbene, 3,5-Dihydroxy-4-isopropylstilbene, GSK-2894512, Tapinarof, WBI 1001
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About This Item
Empirical Formula (Hill Notation):
C17H18O2
CAS Number:
Molecular Weight:
254.32
NACRES:
NA.77
UNSPSC Code:
41121706
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Benvitimod, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, White to Very dark grey
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
CC(C1=C(C=C(C=C1O)/C=C/C2=CC=CC=C2)O)C
InChI
1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+
InChI key
ZISJNXNHJRQYJO-CMDGGOBGSA-N
Biochem/physiol Actions
Aryl hydrocarbon receptor (AHR) immunomodulator that inhibits skin inflammation and enhances skin barrier function.
Benvitimod (Tapinarof) is an aryl hydrocarbon receptor (AHR) immunomodulator that inhibits skin inflammation and enhances skin barrier function. Benvitimod is a metabolite, similar to resveratrol, produced by bacterial symbionts of entomopathogenic nematodes. It induces downregulation of inflammatory cytokines such as IL-17A, IL-17F, IL-19, IL-22, IL-23, and IL-1. Benvitimod also induces the expression of skin barrier genes related to keratinocyte differentiation.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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