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SML3433

NVP-TNKS656

≥98% (HPLC)

Synonym(s):

; N-Cyclopropylmethyl-2-[4-(4-methoxybenzoyl)piperidin-1-yl]-N-[(4-oxo-4,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide, N-​(Cyclopropylmethyl)​-​4-​(4-​methoxybenzoyl)​-​N-​[(3,​5,​7,​8-​tetrahydro-​4-​oxo-​4H-​pyrano[4,​3-​d]​pyrimidin-​2-​yl)​methyl]​-​piperidineacetamide, NVP-TNKS 656, TNKS656

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About This Item

Empirical Formula (Hill Notation):
C27H34N4O5
CAS Number:
1419949-20-4
Molecular Weight:
494.58
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD28167762
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N4(CCC(CC4)C(=O)c5ccc(cc5)OC)CC(=O)N(CC3CC3)Cc1[nH][c](c2c(n1)CCOC2)=O

InChI

1S/C27H34N4O5/c1-35-21-6-4-19(5-7-21)26(33)20-8-11-30(12-9-20)16-25(32)31(14-18-2-3-18)15-24-28-23-10-13-36-17-22(23)27(34)29-24/h4-7,18,20H,2-3,8-17H2,1H3,(H,28,29,34)

InChI key

DYGBNAYFDZEYBA-UHFFFAOYSA-N

Biochem/physiol Actions

NVP-TNKS656 is an orally active, highly potent and selective tankyrase inhibitor. NVP-TNKS656 is a potent antagonist of Wnt pathway that reverts resistance to PI3K and AKT inhibitors in treatment of colorectal cancer.
orally active, highly potent and selective tankyrase inhibitor

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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