SML3446
VT107
≥98% (HPLC), auto-palmitoylation inhibitor, powder
Synonym(s):
(S)-N-(l-(6-Aminopyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2-naphthamide, N-[(1S)-1-(6-Amino-2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide, VT 107
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About This Item
Empirical Formula (Hill Notation):
C25H20F3N3O
CAS Number:
Molecular Weight:
435.44
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
VT107, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Potent pan-TEAD auto-palmitoylation inhibitor with anti-proliferation efficacy against mesothelioma with NF2 defect.
VT107 is a potent pan-TEAD auto-palmitoylation inhibitor (3 μM; using TEAD isotype-overexpressing HEK293T) that blocks TEAD-mediated gene transcription (IC50 = 4.93 nM) by preventing its association with YAP/TAZ. VT107 selectively inhibits the proliferation of mesothelioma cultures with NF2 mutation (NCI-H2051 IC50 = 20.4 nM), deletion (NCI-H2373 IC50 = 9.35 nM) or deficiency (NCI-H226 IC50 = 8.67 nM), but not those with wild-type NF2.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Manon Sturbaut et al.
European journal of medicinal chemistry, 226, 113835-113835 (2021-09-13)
The Hippo pathway is involved in organ size control and tissue homeostasis by regulating cell growth, proliferation and apoptosis. It controls the phosphorylation of the transcription co-activator YAP (Yes associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif) in order
Tracy T Tang et al.
Molecular cancer therapeutics, 20(6), 986-998 (2021-04-15)
Mutations in the neurofibromatosis type 2 (NF2) gene that limit or abrogate expression of functional Merlin are common in malignant mesothelioma. Merlin activates the Hippo pathway to suppress nuclear translocation of YAP and TAZ, the major effectors of the pathway
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