SML3450
PA-8
≥95% (HPLC)
Synonym(s):
2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]-pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione, PA 8
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About This Item
Empirical Formula (Hill Notation):
C17H18N4O4
CAS Number:
Molecular Weight:
342.35
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
PA-8 is a potent and selective PACAP type I (PAC1) receptor agonist that inhibits the phosphorylation of CREB induced by PACAP in PAC1- receptor-expressing CHO cells. PA-8 blocks PACAP-induced aversive responses and mechanical allodynia in mice.
Potent and selective PACAP type I (PAC1) receptor antagonist.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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