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SML3454

Ridaforolimus

≥95% (HPLC)

Synonym(s):

AP23573, Deforolimus, MK-8669

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About This Item

Empirical Formula (Hill Notation):
C53H84NO14P
CAS Number:
572924-54-0
Molecular Weight:
990.21
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD13184816
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

O=C(N1CCCC[C@]12[H])C([C@@]3(O)[C@@H](CC[C@]([H])(O3)C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@H](C([C@@H]([C@H](O)/C(C)=C/[C@H](C(C[C@@]([H])([C@@H](C[C@H]4C[C@@H](OC)[C@@H](CC4)OP(C)(C)=O)C)OC2=O)=O)C)OC)=O)C)C)=O

InChI

1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61,67-40)50(58)51(59)54-25-17-16-20-41(54)52(60)66-45(35(4)28-39-22-24-43(46(29-39)64-9)68-69(11,12)62)31-42(55)34(3)27-37(6)48(57)49(65-10)47(56)36(5)26-32/h13-15,18-19,27,32,34-36,38-41,43-46,48-49,57,61H,16-17,20-26,28-31H2,1-12H3/b15-13+,18-14+,33-19+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

InChI key

BUROJSBIWGDYCN-GAUTUEMISA-N

Related Categories

Biochem/physiol Actions

Antiproliferative mTORC1 inhibitor
Ridaforolimus is an antiproliferative mTOR inhibitor that forms a complex with the FK506 binding protein-12 (FKBP-12), which binds to and inhibits mTOR resulting in cell cycle arrest and inhibition of tumor cell growth and proliferation. Like rapamycin, ridaforolimus affects only mTORC1, not mTORC2.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H373

Hazard Classifications

STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000200774
0000200775
0000187825
0000187825
0000200775

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Global Trade Item Number

SKUGTIN
SML3454-25MG04065268789735
SML3454-5MG04065268789742

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