SML3456
LUF7244
≥98% (HPLC)
Synonym(s):
2-[4-(3-Chlorobenzoyl)phenoxy]-N-3-pyridinyl-acetamide
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About This Item
Empirical Formula (Hill Notation):
C20H15ClN2O3
CAS Number:
Molecular Weight:
366.80
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
LUF7244, ≥98% (HPLC)
InChI key
KKKJYDOHVKIIQP-UHFFFAOYSA-N
SMILES string
O=C(NC1=CC=CN=C1)COC2=CC=C(C=C2)C(C3=CC=CC(Cl)=C3)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
LUF7244 is a potent and selective voltage-gated potassium 11.1 (Kv11.1) channels negative allosteric modulator/activator that inhibits early afterdepolarizations in vitro. It decreases the affinity of Kv11.1 for cisapride, astemizole, dofetilide and sertindole. LUF7244 averts dofetilide‐induced torsades de pointes arrhythmias in dogs with chronic atrioventricular block. LUF7244 in combination with dofetilide rescues both congenital and acquired Kv11.1 trafficking defects and produces functional Kv11.1 current in trafficking defective G601S-Kv11.1 cells.
Potent and selective voltage-gated potassium 11.1 (Kv11.1) channels negative allosteric modulator/activator that inhibits early afterdepolarizations
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Muge Qile et al.
Molecular pharmacology, 97(6), 355-364 (2020-04-04)
Voltage-gated potassium 11.1 (Kv11.1) channels play a critical role in repolarization of cardiomyocytes during the cardiac action potential (AP). Drug-mediated Kv11.1 blockade results in AP prolongation, which poses an increased risk of sudden cardiac death. Many drugs, like pentamidine, interfere
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