SML3460
CB-103
≥97% (HPLC)
Synonym(s):
6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine, CB 103, CB103
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About This Item
Empirical Formula (Hill Notation):
C15H18N2O
CAS Number:
Molecular Weight:
242.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Quality Segment
assay
≥97% (HPLC)
form
powder
color
, White to very dark gray
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
Nc1cnc(cc1)Oc2ccc(cc2)C(C)(C)C
InChI
1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3
InChI key
WHIWGRCYMQLLAO-UHFFFAOYSA-N
Biochem/physiol Actions
CB-103 is an orally active Notch transcription activation inhibitor that targets RBPJ-Notch intracellular domain (NICD) transcription complex assembly. CB-103 exhibits antiproliferation efficacy against Notch-driven cancer growth in cultures (IC50 from 50 nM to 3 μM; patient-derived T-ALL cells positive for N1-ICD) and in tumor models in vivo (10-25 mg/kg qd or bid p.o. to mice with human T-ALL xenografts).
Orally active Notch transcription activation inhibitor with anti-cancer efficacy in cultures and in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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