SML3470
MSC-4381
≥98% (HPLC)
Synonym(s):
5-[2-[5-Chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid, MCT4 probe MSC-4381
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About This Item
Empirical Formula (Hill Notation):
C26H20ClN3O6S
CAS Number:
Molecular Weight:
537.97
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
MSC-4381, ≥98% (HPLC)
InChI key
FNBUZGRPJLEIMO-UHFFFAOYSA-N
SMILES string
O=C(C1=NC=C(C(OC)=C1)C#CC2=CC(Cl)=CC=C2NS(=O)(C3=CC=C(C4=CC=CN=C43)OCC)=O)O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell penetrant highly potent and selective inhibitor of monocarboxylate transporter 4 (MCT4)
MSC-4381 is a cell penetrant highly potent and selective inhibitor of monocarboxylate transporter 4 (MCT4). MSC-4381 potently inhibit lactate efflux and intracellular lactate accumulation in MCT4-expressing cell lines.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology
Journal of Medicinal Chemistry, 64, 11904-11933 (2021)
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