SML3472
ATR-002
≥98% (HPLC)
Synonym(s):
Benzoic acid, 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro- (9CI, ACI)
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About This Item
Empirical Formula (Hill Notation):
C13H7ClF2INO2
CAS Number:
Molecular Weight:
409.55
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C13H7ClF2INO2/c14-8-5-6(17)1-4-10(8)18-12-7(13(19)20)2-3-9(15)11(12)16/h1-5,18H,(H,19,20)
InChI key
XCNBGWKQXRQKSA-UHFFFAOYSA-N
SMILES string
O=C(C1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
ATR-002, a derivate of CI-1040, is a cell penetrant, potent and specific inhibitor of the Raf/MEK/ERK pathway. ATR-002 exhibits strong anti-influenza and anti-SARS-CoV-2 activity. It impairs the influenzas and SARS-CoV-2 viruses induced expression of pro-inflammatory cytokines.
cell penetrant, potent and specific inhibitor of the Raf/MEK/ERK pathway; exhibits strong anti-influenza and anti-SARS-CoV-2 activity
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Martin Laure et al.
Antiviral research, 178, 104806-104806 (2020-04-19)
Antiviral therapies against influenza are required, especially for high-risk patients, severe influenza and in case of highly pathogenic influenza virus (IV) strains. However, currently, licensed drugs that target the virus directly are not very effective and often lead to the
André Schreiber et al.
Cellular and molecular life sciences : CMLS, 79(1), 65-65 (2022-01-12)
Coronavirus disease 2019 (COVID-19), the illness caused by a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to more than 260 million confirmed infections and 5 million deaths to date. While vaccination is a powerful
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