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Merck
CN

SML3506

PD 173212

≥95% (HPLC)

Synonym(s):

(S)-N-((S)-3-(4-(Benzyloxy)phenyl)-1-(tert-butylamino)-1-oxopropan-2-yl)-2-((4-tert-butylbenzyl)(methyl)amino)-4-methylpentanamide, N‐[[4‐(1,1‐Dimethylethyl)phenyl]methyl]‐N‐methyl‐L‐leucyl‐N‐(1,1‐dimethylethyl)‐O‐(phenylmethyl)‐L‐tyrosinamide, PD-173212

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About This Item

Empirical Formula (Hill Notation):
C38H53N3O3
CAS Number:
217171-01-2
Molecular Weight:
599.85
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD12828777

Key Documents

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InChI

1S/C38H53N3O3/c1-27(2)23-34(41(9)25-29-15-19-31(20-16-29)37(3,4)5)36(43)39-33(35(42)40-38(6,7)8)24-28-17-21-32(22-18-28)44-26-30-13-11-10-12-14-30/h10-22,27,33-34H,23-26H2,1-9H3,(H,39,43)(H,40,42)/t33-,34-/m0/s1

SMILES string

O=C([C@@H](NC([C@@H](N(C)CC1=CC=C(C=C1)C(C)(C)C)CC(C)C)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2)NC(C)(C)C

InChI key

GCDHMGROXQUFNR-HEVIKAOCSA-N

assay

≥95% (HPLC)

form

(Powder, lyophilized powder, or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

PD 173212 is a selective N-type (Cav2.2) voltage sensitive calcium channel (VSCC) blocker that potently inhibits VSCC-mediated calcium influx in IMR-32 human neuroblastoma cells (IC50 = 36 nM vs. 8%/Na+ channels & 10% K+ channels blockage at 1 μM, L-type Ca+2 channels IC50 >10 μM) with in vivo efficacy in a murine audiogenic zeisure model (80% tonic zeisure protection at 30 mg/kg i.v.).
Selective N-type voltage-gated calcium channel (VSCC) blocker with in vivo efficacy in a murine audiogenic seizure model.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000200802
0000200802

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