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SML3507

Hirsutine

≥98% (HPLC)

Synonym(s):

(αE,​2S,​3R,​12bR)​-3-​Ethyl-​1,​2,​3,​4,​6,​7,​12,​12b-​octahydro-​α-​(methoxymethylene)​-indolo[2,​3-​a]​quinolizine-​2-​acetic acid methyl ester, (E)-16,17-Didehydro-17-methoxy-17,18-seco-3-beta-yohimban-16-carboxylic acid methyl ester

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About This Item

Empirical Formula (Hill Notation):
C22H28N2O3
CAS Number:
7729-23-9
Molecular Weight:
368.47
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01750089
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

CC[C@@]1([H])CN(CCC2=C3NC4=C2C=CC=C4)[C@]3([H])C[C@]1([H])/C(C(OC)=O)=C\OC

InChI

1S/C22H28N2O3/c1-4-14-12-24-10-9-16-15-7-5-6-8-19(15)23-21(16)20(24)11-17(14)18(13-26-2)22(25)27-3/h5-8,13-14,17,20,23H,4,9-12H2,1-3H3/b18-13+/t14-,17-,20+/m0/s1

InChI key

NMLUOJBSAYAYEM-AZQGJTAVSA-N

Biochem/physiol Actions

Anti-cancer, cardioprotective, anti-hypertensive, and anti-arrhythmic activities
Hirsutine is a brain penetrant alkaloid from Uncaria rhynchophylla that exhibit anti-cancer, cardioprotective, anti-hypertensive, and anti-arrhythmic activities. It appears that hirsutine induces apoptosis in lung cancer cells through opening of mitochondrial permeability transition pore (mPTP). Hirsutine exhibit potent anti-dengue virus activity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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