SML3508
Intepirdine
≥98% (HPLC)
Synonym(s):
3-(Phenylsulfonyl)-8-(1-piperazinyl)quinoline, 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline, GSK 742457, RVT 101, SB-742457
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About This Item
Empirical Formula (Hill Notation):
C19H19N3O2S
CAS Number:
Molecular Weight:
353.44
UNSPSC Code:
51111800
NACRES:
NA.21
MDL number:
InChI key
JJZFWROHYSMCMU-UHFFFAOYSA-N
SMILES string
O=S(C1=CC=CC=C1)(C2=CC3=C(N=C2)C(N4CCNCC4)=CC=C3)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Brain blood barrier penetrant, orally available, potent and selective serotonin receptor 6 (5-HT6) receptor antagonist
Intepirdine (SB-742457) is a brain blood barrier penetrant, orally available, potent and selective serotonin receptor 6 (5-HT6) receptor antagonist that potentiate cognitive and the behavioral abnormalities of AD in laboratory set up. Intepirdine has failed to demonstrate statistically significant impact on cognition or dementia in phase III trials. Intepirdine promotes satiety.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
Neurotherapeutics, 5(3), 458-469 (2008)
The 5-HT?C receptor agonist, lorcaserin, and the 5-HT? receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour
Psychopharmacology, 233(3), 417-424 (2016)
5-HT6 receptor agonist and antagonist improve memory impairments and hippocampal BDNF signaling alterations induced by MK-801
Brain Research, 1722, 146375-146375 (2019)
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